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(1) Stimulate chondrocytes to synthesize Col-II and proteoglycans, while inhibiting the activities of MMP-13 and ADAMTS-5, and reducing matrix degradation

[1] CoQ10 also scavenges harmful free radicals, playing a pivotal role in your antioxidant status and overall health and vitality

The first is a shorter duration between final dose of combination therapy to resumption of an ICI, and the second is the use of steroids at the time of restart